Amoxil capsules 500mg, the authors say, can improve cardiovascular health and prevent disease. However, the drug may increase risk of heart attack in at-risk individuals and is highly toxic to cells of the red blood cell and tissue of the heart. In the study, 24 healthy men were randomly assigned to receive four tablets, an effective dosage, or placebo. Participants completed the cardiovascular activity test in a random sequence for 4 hours. Blood samples were taken immediately before the test and at conclusion. Participants were asked to fast for 6 hours before and after taking capsules followed the same food intake for 24 hours before blood draws. Heart rates, pressure, and physical performance were measured at each test. The subjects' heart rates during exercise were 2% higher (by 0.9 mm Hg) compared to the placebo group. However, resting blood pressure and stress hormone level were normal in all subjects at completion. Heart rate did not differ by gender, although subjects in the placebo group had fewer body mass indexes (BMIs) than those assigned to the IV fenofibrate regimen. The authors say that: The results from this cross-sectional study suggest that an oral fenofibrate regimen could be beneficial in an age- and gender-matched cardiovascular population in terms of reduced cardiovascular risk. However, the potential benefits of use fenofibrate in cardiovascular disease prevention should also be explored in larger studies pre-clinical models and in large-scale clinical trials. A higher dose doesn't appear to lead more rapid absorption and clearance of the drug As previously noted, fenofibrate's cardiovascular effects are not significantly altered by higher doses. In this study, the authors also note that: The authors conclude that "fenofibrate (250 mg/day) can improve cardiovascular risk factors when administered for an additional 14 days." They added: "Furthermore, fenofibrate therapy in healthy patients at the usual dosages in healthy male volunteers for up to 14 days could alleviate symptoms [of heart failure], which is similar to the benefits of therapy with atorvastatin." This may explain why the authors have proposed a fenofibrate-as-well-as-atorvastatin-as-a-single-therapy combo. Interestingly, they report that a single oral dose of fenofibrate doesn't seem to lead more rapid absorption and clearance of the drug, compared to IV fenofibrate. Other researchers are not convinced. "The fact that there is no difference in absorption or clearance suggests that if there is benefit from this regimen – as a single therapy it may be from fewer side effects the multiple drugs (fenofibrate and atorvastatin)," argues John Yacoub, a professor of cardiology at University College London. Yacoub notes that because atorvastatin has an adverse history of increased blood pressure and heart valve dysfunction, "it cannot be recommended as a first choice drug." Despite this, Yacoub adds: "What might be the benefit for fenofibrate would be the benefits for patient and health care system: more efficient treatment based on the pharmacokinetics of a single compound that have been well established." One way to test fenofibrate's potential role in reducing cardiovascular disease risk would be to study how fenofibrate stacks up with other medications currently used to treat, for example, high blood pressure or cardiovascular surgery. Fenofibrate may also be especially useful in patients who are on long-.
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